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desvenlafaxine will improve the stage or influence of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by as many as 50%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive days strai